The transcription factor Gli3 is acting mainly as a transcriptional repressor in the Sonic hedgehog signal transduction pathway.Gli3 contains a repressor domain in its N-terminus from residue G106 to E236.In this study we have characterized the intracellular structure of the Gli3 repressor domain using a combined bioinformatics and experimental app
Abstract The therapeutic landscape in metastatic melanoma has changed dramatically in the last decade, with the success of immune checkpoint inhibitors resulting in durable responses for a large number of patients.For patients with BRAF mutations, combinations of BRAF and MEK inhibitors demonstrated response rates and benefit comparable to those fr
Inferior accessory ossicle of anterior arch of atlas is a rare, albeit normal variant in relation to the cervical spine, invariably detected incidentally while investigating for other unrelated condition.Its existence should always be kept in mind while evaluating any bony emtek 2113 fragment in relation to atlas axis vertebrae so as to avoid unnec
In the title compound, C11H6N2O, the complete molecule is generated by the sennheiser ba 70 application of crystallographic twofold symmetry (the molecule is disordered about this axis).The prop-2-yn-1-yl residue is slightly twisted out of the plane of the benzene ring [C—O—C—C torsion angle = 173.1 (3)&#